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| Karimzadeh,Latifeh; Nabiuni,Mohammad; Kouchesfehani,Homa Mohseni; Adham,Hamed; Bagheri,Amir; Sheikholeslami,Azar. |
| Background : Polycystic ovarian syndrome (PCOS) is a low-grade inflammatory disease characterized by hyperandrogenemia, hirsutism, chronic anovulation and vascular disorder. Interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are triggered by inflammatory stimuli and lead to angiogenesis and pathogenesis of the ovary. Honeybee venom (HBV) contains an array of biologically active components possessing various pharmaceutical properties. This study was designed to assess the possibility of HBV application as an anti-inflammatory therapeutic agent to suppress levels of the main inflammatory mediators IL-6, COX-2 and VEGF. To induce PCOS, 1 mg of estradiol valerate (EV) per 100 g of body weight was subcutaneously (SC)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polycystic ovarian syndrome; Honeybee venom; Interlukin-6; Cyclooxygenase-2; Vascular endothelial growth factor. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100317 |
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| Salvetti,Natalia R.; Canal,Ana M.; Gimeno,Eduardo J.; Ortega,Hugo H.. |
| Numerous experimental models have been developed for the study of the polycystic ovarian syndrome in the rat. In the present study, the syndrome was induced by exposure to constant light. The process was evaluated during its induction and also during its reversion. The estral cycle was analyzed through the vaginal cytology; reproductive parameters were evaluated by mating, as well as the ovarian morphology. All the animals developed the syndrome after 13 weeks of permanent light. The histologic characteristics of the ovaries, at week 15, were similar to those observed in the polycystic ovarian syndrome in human and other species. After regression of the syndrome, there was not difference in any of the evaluated reproductive parameters, when compared with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Histopathology; Ovary; PCOD; Polycystic ovarian syndrome; Rat. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962004000600006 |
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